Eastern Airways will resume services from George Best Belfast City Airport to initially include Southampton and Teesside.
From 22 June, a daily weekday service to both hubs will be the first to be introduced. The frequency will be increased as appropriate through July, August and September.
Roger Hage, Eastern Airways' general manager of commercial and operations, said: "We are pleased to announce that our initial Belfast City Airport flights are returning with a carefully considered re-start frequency to support the major regions of the UK and ensure regional connectivity returns given its vital role in recovering economic prosperity.
"We will continue to increase frequency, including the return of weekend services, as demand returns along with adding new routes to our network."
Katy Best, commercial director at Belfast City Airport, added: "The last few months have seen the airport operate a significantly reduced schedule to London to facilitate essential travel.
"The wellbeing of our staff and passengers is of paramount importance and measures are in place throughout the terminal to enable social distancing with signage visible throughout the airport."
Source: Insider Media Limited